STENDRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take STENDRA if you take any medicines called nitrates. Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.
Do not take STENDRA if you take medicines called guanylate cyclase stimulators which include:
• Riociguat and vericiguat, medicines that treat pulmonary arterial hypertension and chronic-thromboembolicpulmonary hypertension.
Ask your healthcare provider or pharmacist if any of your medicines are nitrates or guanylate cyclase stimulators.
Tell all your healthcare providers that you take STENDRA. If you need emergency medical care for a heartproblem, it will be important for your healthcare provider to know when you last took STENDRA.
Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea attack or heart disease.

STENDRA is a prescription medicine used to treat erectile dysfunction (ED) in adult men.
STENDRA is not for use in women or children.
It is not known if STENDRA is safe and effective in women or children under 18 years of age.

• take medicines called nitrates.
• use street drugs called “poppers” such as amyl nitrite and butyl nitrite.
• are allergic to avanafil or any of the ingredients in STENDRA. See the end of this leaflet for a complete list of ingredients in STENDRA.
• take any medicines called guanylate cyclase stimulators.


Before you take STENDRA, tell your healthcare provider about all of your medical conditions, including if you:

• have or have had heart problems such as a heart attack, irregular heartbeat, angina, or heart failure.
• have had heart surgery within the last 6 months.
• have had a stroke.
• have low blood pressure, or high blood pressure that is not controlled.
• have a deformed penis shape.
• have had an erection that lasted for more than 4 hours.
• have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia.
• have retinitis pigmentosa, a rare genetic (runs in families) eye disease.
• have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy(NAION).
• have had a sudden decrease or loss of hearing.
• have bleeding problems.
• have or have had stomach ulcers.
• have liver problems.
• have kidney problems or are having kidney dialysis. 

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 
STENDRA may affect the way other medicines work, and other medicines may affect the way STENDRA works
causing side effects. Especially tell your healthcare provider if you take any of the following: 
• medicines called nitrates (see What is the most important information I should know about STENDRA?)
• medicines called guanylate cyclase stimulators, such a riociguat or vericiguat (see What is the most importantinformation I should know about STENDRA?)
• medicines called HIV protease inhibitors.
• some types of oral antifungal medicines, such as ketoconazole, and itraconozale.
• some types of antibiotics, such as clarithromycin, telithromycin, or erythromycin.
• medicines called alpha blockers. These include terazosin, tamsulosin HCl, doxazosin, prazosin HCl, alfuzosin HCl,
dutasteride and tamsulosin HCl, or silodosin. Alpha-blockers are sometimes prescribed for prostate problems or
high blood pressure. In some patients, the use of STENDRA with alpha-blockers can lead to a drop in blood
pressure or to fainting.
• other medicines that treat high blood pressure.
• other medicines or treatments for ED. 
Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. 
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a
new medicine.

• Take STENDRA exactly as your healthcare provider tells you to take it.
• Your healthcare provider will tell you how much STENDRA to take and when to take it.
• Take STENDRA 100 mg or 200 mg as early as 15 minutes before sexual activity or
• Take STENDRA 50 mg as early as 30 minutes before sexual activity.• Do not take STENDRA more than 1 time a day.
• Some form of sexual stimulation is needed for an erection to happen after taking STENDRA.
• Your healthcare provider may change your dose if needed.
• You should take the lowest dose of STENDRA that works for you. You and your healthcare provider should decide
about the lowest dose of STENDRA that works for you.
• STENDRA may be taken with or without food.
• If you take too much STENDRA, call your healthcare provider or go to the nearest hospital emergency room rightaway.

• Do not drink too much alcohol when taking STENDRA (for example, 3 glasses of wine, or 3 shots of whiskey).
Drinking too much alcohol when taking STENDRA can increase your chances of increasing your heart rate,
lowering your blood pressure, dizziness or getting a headache.

STENDRA can cause serious side effects, including:
• See “What is the most important information I should know about STENDRA?”
• an erection that will not go away (priapism). If you have an erection that lasts more than 4 hours, get medical
help right away. If it is not treated right away, priapism can permanently damage your penis.
• sudden vision loss in 1 or both eyes. Sudden vision loss in 1 or both eyes can be a sign of a serious eye
problem called non-arteritic anterior ischemic optic neuropathy (NAION). It is uncertain whether PDE5 inhibitors
such as STENDRA, directly cause vision loss. Stop taking STENDRA and call your healthcare provider right away
if you have sudden vision loss in 1 or both eyes.
• sudden hearing decrease or hearing loss. Some people may also have ringing in their ears (tinnitus) or
dizziness.
The most common side effects of STENDRA are:
• headache
• flushing
• stuffy or runny nose
• sore throat
• back pain
These are not all of the possible side effects of STENDRA.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• Store STENDRA at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep STENDRA out of the light.
Keep STENDRA and all medicines out of the reach of children

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use
STENDRA for a condition for which it was not prescribed. Do not give STENDRA to other people, even if they have
the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for
information about STENDRA that is written for health professionals.

Active ingredient: avanafil.